Functional consequences of iron deficiency in human populations.

Functional consequences of iron deficiency in human populations.

The widespread occurrence of iron deficiency in developing countries is now well documented. Its high prevalence in these countries is attributable not only to the poor availability of iron in diets because of high fiber and phytate content, but also to chronic blood losses due to hookworm, schisto somiasis, and malaria (1). A high prevalence of iron deficiency anemia obviously means an equal o...

Muscle specific iron deficiency has systemic consequences

Iron is an essential element for most prokaryotes and all eukaryotes. the skeletal muscle specific actin promoter driving the Cre recombinase Iron is required for heme synthesis, iron–sulfur cluster synthesis and as a co-factor for awide variety of enzymes.Most of the iron in vertebrates is found in hemoglobin in red blood cells and iron deficiency anemia is a significant medical problem. Iron,...

Behavioral consequences of developmental iron deficiency in infant rhesus monkeys.

Human studies have shown that iron deficiency and iron deficiency anemia in infants are associated with behavioral impairment, but the periods of brain development most susceptible to iron deficiency have not been established. In the present study, rhesus monkeys were deprived of iron by dietary iron restriction during prenatal (n=14, 10 microg Fe/g diet) or early postnatal (n=12, 1.5 mg Fe/L f...

Long-term brain and behavioral consequences of early iron deficiency.

Early iron deficiency not only affects brain and behavioral function during the period of iron deficiency, it persists long after treatment. The mechanisms include long-term alterations in dopamine metabolism, myelination, and hippocampal structure and function. Recent studies have demonstrated long-term genomic changes, which suggests the regulation of brain function is fundamentally altered.

Iron enzymes in iron deficiency. II. Catalase in human erythrocytes.